Centers for Disease Control and Prevention (CDC) indicated the US with millions of adults involved in different types of chronic pains. That’s why nearly every drugstore is filled with products for topical pain relief. Topical pain relief creams help in easing discomfort associated with a different condition that causes pain.

Some people prefer using creams they have been using for years and some people find the best pain relief cream is an unending quest due to numerous reasons including an abundance of choices and undesirable outcomes from the product.

Every year hundreds of brands worldwide evolved which makes the market for pain relief creams extremely saturated. Finding the top picks from an infinite number of brands on the market is a big deal that’s why shrinking the options for consumers is the best that we could do. Based on performance relief and maximum effect here are some widely considered best pain relief creams to look for when needed.

5 Best Pain Relief Creams

Below are the 5 best topical pain relief creams, each of which has its own unique use and is known for effectiveness by experts:

1. Penetrex Pain Relief Cream

Penetrex Pain Relief Cream is great for alleviating pain in a variety of conditions. This cream contains soothing ingredients and is loved by users for non -greasy texture and light feel. Overall this cream combines all attributes of a good pain reliever including texture, smell, and effectiveness that’s why it is rated high on the list.

2. Biofreeze Pain Relief Gel Roll-On

Biofreeze’s Pain Relief Gel Roll-On is a Colorless Topical Pain Reliever that targets pains related to Arthritis, Backache, Strains, Bruises, & Sprains. It provides fast action and long-lasting, relief with a cooling menthol formula strong enough for common aches and pains. Its roll-on design allows a mess-free application and massaging effect. Menthol is the active ingredient in Biofreeze which provides soothing and cooling relief.

3. Tiger Balm Neck & Shoulder Pain Relief Cream

Tiger Balm Neck & Shoulder Cream provides fast, relief for neck and shoulder pain and the aches caused by daily work is formulated with active ingredients like camphor and cooling menthol which are two common topical analgesics that help relieve minor muscle or joint discomfort. Tiger Balm has been used for nearly 100 years and can be found on any drug store shelf easily. Tiger balm works effectively on back pain as well.

4. Noxicare’s Natural Pain Relief Cream

Noxicare’s natural pain relief cream has both pain-relieving and anti-inflammatory properties. This cream contains natural ingredients turmeric, ginger, and rosemary extract which are best for alleviating discomfort and pain. This cream has no odor thus it can be used anytime when pain occurs. Its formula works slowly and gradually.

5. Muscle-Mechanics Pain-Relief-Balm

Muscle-mechanics pain-relief-balm is a new and effective addition to the pain relief creams list. It’s a small pocket-size balm containing numbing and cooling agents that provide fast relief from aches and pain in a variety of conditions. It effectively combats inflammation and reduces pain response in the body.

Potential Benefits of Pain Relief Creams

Pain relief creams, also known as topical analgesics are applied directly to the skin to alleviate pain and discomfort. These creams can be used to treat a variety of conditions, including arthritis, muscle soreness, and injuries. Here are some potential benefits of using pain relief creams:

Targeted Pain Relief

Pain relief creams are designed to be applied directly to the affected area, providing targeted pain relief where it is needed most. This means that the medication is delivered to the source of the pain, rather than having to go through the bloodstream, which can take longer to provide relief.


Pain relief creams are a non-invasive method of pain relief, which means that they do not require injections, surgery, or other invasive procedures. This can be a more appealing option for those who are afraid of needles or surgery.

Minimal Side Effects: 

Pain relief creams are generally safe and have minimal side effects. Unlike oral medications, which can cause stomach upset or other side effects, topical analgesics are less likely to cause systemic side effects.


Pain relief creams are easy to apply and can be used as needed throughout the day. They are also portable, making them a convenient option for those who are on the go.

Reduced Need for Oral Pain killers: 

Pain relief creams can be an effective alternative to oral pain medications, which can have more significant side effects and risks of addiction. This can be especially beneficial for those who are dealing with chronic pain and need to manage their symptoms on a long-term basis.


These products are considered alternative treatments for the temporary relief of a variety of acute and chronic pain conditions. Choosing topical pain relief cream should be based on your symptoms and condition.

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